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Ute Spiekerkoetter Selected Research

Long-Chain Acyl-CoA Dehydrogenase (Long-Chain-Acyl-Coenzyme A Dehydrogenase)

1/2020Sex-specific perturbation of complex lipids in response to medium-chain fatty acids in very long-chain acyl-CoA dehydrogenase deficiency.
11/2019The fate of medium-chain fatty acids in very long-chain acyl‑CoA dehydrogenase deficiency (VLCADD): A matter of sex?
11/2015De novo fatty acid biosynthesis and elongation in very long-chain acyl-CoA dehydrogenase-deficient mice supplemented with odd or even medium-chain fatty acids.
7/2015Sexual dimorphism of lipid metabolism in very long-chain acyl-CoA dehydrogenase deficient (VLCAD-/-) mice in response to medium-chain triglycerides (MCT).
12/2014Renal response to short- and long-term exercise in very-long-chain acyl-CoA dehydrogenase-deficient (VLCAD(-/-)) mice.
5/2014Development and pathomechanisms of cardiomyopathy in very long-chain acyl-CoA dehydrogenase deficient (VLCAD(-/-)) mice.
1/2014Monounsaturated 14:1n-9 and 16:1n-9 fatty acids but not 18:1n-9 induce apoptosis and necrosis in murine HL-1 cardiomyocytes.
4/2013Long-term dietary effects on substrate selection and muscle fiber type in very-long-chain acyl-CoA dehydrogenase deficient (VLCAD(-/-)) mice.
1/2012Tissue-specific strategies of the very-long chain acyl-CoA dehydrogenase-deficient (VLCAD-/-) mouse to compensate a defective fatty acid β-oxidation.
12/2011Hepatic and muscular effects of different dietary fat content in VLCAD deficient mice.
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Ute Spiekerkoetter Research Topics

Disease

18VLCAD deficiency
01/2020 - 09/2003
10Trifunctional Protein Deficiency With Myopathy And Neuropathy
05/2022 - 12/2002
6Cardiomyopathies (Cardiomyopathy)
10/2020 - 08/2008
4Muscular Diseases (Myopathy)
10/2020 - 10/2010
4Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2020 - 08/2011
3Glycogen Storage Disease (Glycogenosis)
07/2022 - 01/2020
3Peripheral Nervous System Diseases (PNS Diseases)
05/2022 - 01/2004
3Hypoglycemia (Reactive Hypoglycemia)
04/2021 - 10/2010
3Tyrosinemias (Tyrosinemia)
02/2011 - 03/2010
2Glycogen Storage Disease IB
07/2022 - 01/2020
2Neutropenia
07/2022 - 01/2020
2Propionic Acidemia
11/2021 - 01/2016
2Inborn Genetic Diseases (Disease, Hereditary)
07/2021 - 10/2019
2Inborn Errors Metabolism (Inborn Errors of Metabolism)
04/2021 - 07/2020
2Glycogen Storage Disease Type VI (Glycogenosis Type VI)
03/2021 - 01/2021
2Gaucher Disease (Gaucher's Disease)
01/2021 - 01/2020
2Medium chain acyl CoA dehydrogenase deficiency
01/2021 - 01/2012
2Hepatomegaly
01/2021 - 11/2010
2Vitamin B 12 Deficiency (Vitamin B12 Deficiency)
01/2017 - 01/2016
2Cognitive Dysfunction
03/2012 - 02/2011
2HELLP Syndrome
10/2010 - 02/2004
2Hemolysis
10/2010 - 02/2004
1Infections
07/2022
1Atherosclerosis
11/2021
1Fanconi Syndrome (Syndrome, Fanconi)
11/2021
1Fetal Growth Retardation (Intrauterine Growth Retardation)
04/2021
1Craniofacial Abnormalities
04/2021
1Seizures (Absence Seizure)
04/2021
1Megalencephaly
04/2021
1Silver-Russell Syndrome
04/2021
1Metabolic Diseases (Metabolic Disease)
04/2021
1Succinyl-CoA:3-oxoacid CoA transferase deficiency
04/2021
1Hyperlactatemia
01/2021
1Cholestasis
01/2021
1Glycogen Storage Disease Type Ix
01/2021
1Ascites
01/2021
1Hypertriglyceridemia
01/2021
1Liver Cirrhosis (Hepatic Cirrhosis)
01/2021
1Cardiac Sudden Death (Sudden Cardiac Arrest)
10/2020
1Liver Diseases (Liver Disease)
07/2020
1Wounds and Injuries (Trauma)
01/2020
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2020
1Neoplasms (Cancer)
10/2019
1Maple Syrup Urine Disease
12/2018
1Deglutition Disorders (Dysphagia)
02/2017
1Euthyroid Sick Syndromes (Euthyroid Sick Syndrome)
11/2016
1Hypothyroidism
11/2016

Drug/Important Bio-Agent (IBA)

16Long-Chain Acyl-CoA Dehydrogenase (Long-Chain-Acyl-Coenzyme A Dehydrogenase)IBA
01/2020 - 09/2003
14Fatty Acids (Saturated Fatty Acids)IBA
01/2021 - 01/2004
10EnzymesIBA
11/2021 - 06/2003
7Mitochondrial Trifunctional ProteinIBA
05/2022 - 01/2004
6GlycogenIBA
03/2021 - 12/2014
5Triglycerides (Triacylglycerol)IBA
11/2015 - 09/2010
4Biomarkers (Surrogate Marker)IBA
01/2021 - 01/2016
4Carnitine (L-Carnitine)FDA LinkGeneric
10/2020 - 09/2006
3Liver GlycogenIBA
11/2021 - 07/2020
3Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric
04/2021 - 01/2020
3Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)IBA
01/2021 - 10/2010
3Palmitoyl Coenzyme A (Palmitoyl CoA)IBA
12/2014 - 09/2006
3Tyrosine (L-Tyrosine)FDA Link
03/2012 - 03/2010
2Sodium-Glucose Transporter 2 InhibitorsIBA
07/2022 - 01/2020
2empagliflozinIBA
07/2022 - 01/2020
2LipidsIBA
11/2021 - 01/2020
2Proteins (Proteins, Gene)FDA Link
11/2021 - 02/2004
2Propionyl-Coenzyme A Carboxylase (Propionyl CoA Carboxylase)IBA
11/2021 - 01/2016
2Sulfhydryl Compounds (Thiols)IBA
07/2021 - 10/2019
2TransferasesIBA
04/2021 - 01/2014
2Coenzyme A (CoA)IBA
04/2021 - 10/2010
2Methionine (L-Methionine)FDA Link
10/2019 - 01/2016
11-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase)IBA
11/2021
1C-Reactive ProteinIBA
11/2021
1Galactose (Galactopyranose)FDA LinkGeneric
11/2021
1Hydrogen Sulfide (Sulfide, Hydrogen)IBA
07/2021
1SRS-AIBA
04/2021
1Growth Hormone (Somatotropin)IBA
04/2021
1Hypoglycemic Agents (Hypoglycemics)IBA
04/2021
1succinyl-coenzyme A (succinyl-CoA)IBA
04/2021
1CeramidesIBA
01/2021
1Phosphorylases (Glucan Phosphorylase)IBA
01/2021
1Transaminases (Aminotransferases)IBA
01/2021
1SphingomyelinsIBA
01/2021
1Glycogen Phosphorylase (Phosphorylase, Glycogen)IBA
01/2021
1Transcobalamins (Transcobalamin II)IBA
01/2021
1Phosphorylase Kinase (Phosphorylase Kinase, Glycogen)IBA
01/2021
1Glucosylceramidase (Glucocerebrosidase)IBA
01/2021
1Systemic carnitine deficiencyIBA
10/2020
1beta-GlucosidaseIBA
01/2020
1SaposinsIBA
01/2020
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
01/2020
11,5-anhydroglucitolIBA
01/2020
1PPAR gammaIBA
01/2020
1Mechanistic Target of Rapamycin Complex 1IBA
01/2020
1Vitamin B Complex (B Vitamins)IBA
10/2019
1Sulfides (Thioethers)IBA
10/2019
1Branched-Chain Amino AcidsIBA
12/2018
1BariumIBA
02/2017
1Hormones (Hormone)IBA
11/2016

Therapy/Procedure

2Therapeutics
04/2021 - 01/2021
1Cesarean Section (Caesarean Section)
07/2022
1Thoracotomy
02/2017